Application of 355-80-6, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 355-80-6, name is 2,2,3,3,4,4,5,5-Octafluoro-1-pentanol. This compound has unique chemical properties. The synthetic route is as follows.
General procedure: To a solution of 64.7 mmol of organyl dichlorophosphite 3 in 150 mL of an organic solvent [diethyl ether (3a), dichloromethane(60 mL) (3b), hexane (3c, 3d)] was added dropwise with stirring a solution of 155 mmol of polyfluoroalkanol 4 or 5 and 155 mmol ( 15.7 g) of triethylamine in 30 mL of the corresponding solvent for 1-2 h at low temperature [-10-8C (3a, 3b), -30-25C (3c, 3d), dry ice-acetone]. The formation of a white precipitate of triethylamine hydrochloride was observed. The reaction mixture was stirred for 1-2 h at room temperature, argon was passed to remove HCl, and the mixture was kept overnight in the case of obtaining compounds 6a and 6b. The precipitate (triethylamine hydrochloride) was filtered off, washed (3 × 30 mL) with diethyl ether (3a) or hexane (3b-3d). Washings and the filtrate were combined, the solvents were distilled off under reduced pressure, and the residue was distilled in vacuum. To prevent symmetrization of the aryl bis(polyfluoroalkyl) phosphites 6c and 6d, the distillation flask was placed into a heated glycerin bath (100-120) and distillation was carried out rapidly.
According to the analysis of related databases, 355-80-6, the application of this compound in the production field has become more and more popular.
Reference:
Article; Arbuzova, S. N.; Belogorlova, N. A.; Bishimbayeva, G. K.; Chernysheva, N. A.; Gusarova, N. K.; Malysheva, S. F.; Nalibayeva, A. M.; Oparina, L. A.; Trofimov, B. A.; Verkhoturova, S. I.; Yas?ko, S. V.; Russian Journal of General Chemistry; vol. 90; 5; (2020); p. 839 – 844; Zh. Obshch. Khim.; vol. 90; 5; (2020); p. 744 – 750;,
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