Electric Literature of 33420-52-9, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 33420-52-9, name is 2,2-Difluoropropan-1-ol. A new synthetic method of this compound is introduced below.
General procedure: A mixture of 5-chloro-3-[(2-chlorophenyl)methyl]-7-(3,3-difluoropyrrolidin-l- yl)triazolo[4,5-d]pyrimidine (example 8, step a) (38.5 mg, 0.1 mmol), 2,2,2-Trifluoro- ethanol (99 mg, 1 mmol) and NaH (suspension in oil, 20 mg, 5 mmol) in DMF (1 mL) was stirred at 110 C for 6 h. After cooling to room temperature formic acid was added and the mixture was subjected to purification by preparative HPLC on reversed phase eluting with a gradient formed from acetonitrile, water and formic acid. After evaporation of the product containing fractions 29.3 mg (65 %) of the title compound was isolated. MS(m/e): 449.2 (MH+). Example 53; 3-[(2-Chlorophenyl)methyl]-5-(2,2-difluoropropoxy)-7-(3,3-difluoropyrrolidin-l- yl)triazolo[4,5-d]pyrimidine; In analogy to the procedure described for the synthesis of 3-[(2-chlorophenyl)methyl]-7- (3,3-difluoropyrrolidin-l-yl)-5-(2,2,2-trifluoroethoxy)triazolo[4,5-d]pyrimidine (example 40) the title compound was prepared from 5-chloro-3-[(2-chlorophenyl)methyl]-7-(3,3- difluoropyrrolidin-l-yl)triazolo[4,5-d]pyrimidine and 2,2-difluoropropan-l-ol with the use of Cs2C03 instead of NaH. MS(m/e): 445.3 (MH+).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,33420-52-9, its application will become more common.
Reference:
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; ROEVER, Stephan; ROGERS-EVANS, Mark; NETTEKOVEN, Matthias; SCHMITT, Sebastien; GRETHER, Uwe; KIMBARA, Atsushi; WO2015/32769; (2015); A1;,
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