Related Products of 150192-39-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 150192-39-5, name is (2-Bromo-5-methoxyphenyl)methanol, molecular formula is C8H9BrO2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Example 2; 2- [(2-Bromo-5-methoxybenzyl) oxy]-7-methoxynaphthalene [0045]; To a solution of 7-methoxy-2-naphthol (26.92 g, 0.15 moles), 2-bromo- 5-methoxybenzyl alcohol (33.58 g, 0.15 moles), and triphenylphosphine (39.3 g, 0.15 moles) in anhydrous THF (500 mls) was added a solution of DEAD (26.10 g, 0.15 moles) in THE (100 mL) dropwise over 0.5 hr. The solution was stirred at room temperature overnight and, upon evaporation of half the volume, the product precipitated in good purity. The solid was filtered and rinsed with THF, then dried to yield 32.96 g (59%) of a white solid: mp 156-157 C ; 1H NMR (DMSO-d6): 6 3.77 (3H, s), 3.86 (3H, s), 5.18 (2H, s), 6.92 (1H, dd, J=3. 2 Hz, J=8. 7 Hz), 7.00 (1H, dd, J=2. 4 Hz, J=8. 7 Hz), 7.09 (1H, dd, J=2. 4 Hz, J=8. 9 Hz), 7.22 (1H, d, J=3. 2 Hz), 7.25 (1H, d, J=2. 4 Hz), 7.35 (1H, d, J=2. 4 Hz), 7.59 (1H, d, J=8. 7 Hz), 7.74 (1H, d, J=8. 7 Hz), 7.76 (1H, d, J=8. 7 Hz); MS mlz 373/375 ( [M+H] +). Anal. for ClsHl7BrO3 : Calc’d: C: 61.14 ; H: 4.59 Found: C: 61.29 ; H: 4.21
According to the analysis of related databases, 150192-39-5, the application of this compound in the production field has become more and more popular.
Reference:
Patent; WYETH; WO2005/82880; (2005); A1;,
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