Application of 94022-96-5 ,Some common heterocyclic compound, 94022-96-5, molecular formula is C9H9F3O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
To a mixture of alcohol 1 (1 mmol), the O, Se acetal 2a (1.4 mmol), solid potassium carbonate (2.0 mmol) and activated 3 A molecular sieves (0.20 g) in dry ethyl acetate (16 mL), solid N-iodosuccinimide (1.4 mmol) was added in portion at room temperature. The mixture was stirred under inert atmosphere and monitored by TLC. Reaction times ranged from 0.5 to 2 h. The brown colored reaction mixture was quenched into 20 mL of 10% aqueous sodium thiosulfate pentahydrate solution, mixed, and separated. The aqueous phase was extracted with 10 mL of ethyl acetate and the combined organic phases were washed with 10 mL of brine, dried over sodium sulfate and concentrated. Purification by silica gel column chromatography afforded the MOM-ether derivative 3.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,94022-96-5, its application will become more common.
Reference:
Article; Temperini, Andrea; Annesi, Diego; Testaferri, Lorenzo; Tiecco, Marcello; Tetrahedron Letters; vol. 52; 25; (2011); p. 3179 – 3182;,
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