Application of 41175-50-2 ,Some common heterocyclic compound, 41175-50-2, molecular formula is C12H15NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
To 10 mL DMF at 0oC was added dropwise POCl3 (1.73 mL, 18.5 mmol). The solution was stirred at 0oC for 15 min and then a solution of 3 (3.190 g, 16.9 mmol) in 11 mL DMF was added. The reaction was allowed to be stirred overnight at 0oC to rt. After that the reaction mixture was stirred at 0oC for 0.5 h and quenched by 10 mL water. After stirring for 15 min at rt, the reaction mixture was extracted with EtOAc and washed with water. The organic phase was dried over MgSO4 and evaporated under reduced pressure. The afforded syrup was subjected to flash chromatography purification (hexanes:EtOAc:CHCl3, 6:1:1) to give the product as a purple solid (3.080 g, yield: 84%). 1H NMR (400 MHz, CDCl3) d 11.79 (s, 1 H), 9.35 (s, 1 H), 6.82 (s, 1 H), 3.25 (m, 4 H), 2.66 (m, 4 H), 1.91 (m, 4 H).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 41175-50-2, 1,2,3,5,6,7-Hexahydropyrido[3,2,1-ij]quinolin-8-ol, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Liu, Songbai; Wang, Wu-Hong; Dang, Ya-Li; Fu, Yuanqing; Sang, Ruocheng; Tetrahedron Letters; vol. 53; 32; (2012); p. 4235 – 4239;,
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