Adding a certain compound to certain chemical reactions, such as: 10602-04-7, (4-Ethynylphenyl)methanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Safety of (4-Ethynylphenyl)methanol, blongs to alcohols-buliding-blocks compound. Safety of (4-Ethynylphenyl)methanol
(4-((4-isopropoxy-3-methylphenyl)ethynyl)phenyl)methanolA solution of (4-ethynylphenyl)methanol (CAS 10602-04-7) (250 mgs, 1.9 mmol) in THF was treated with copper (I) iodide (7.2 mgs, 0.04 mmol) and then purged with Argon for 5 minutes. 4-iodo-1-isopropoxy-2-methylbenzene (CAS 877603-52-6) (579 mgs, 2.0 mmol), was then added followed by dichlorobis-(triphenylphosphine) palladium(II) (13.4 mgs, 0.019 mmol).The resultant mixture was heated at 80° C. overnight.The reaction mixture was filtered and the filtrate was evaporated to give the crude product.The crude product was purified on a column (MPLC) using hexane:ethyl acetate and gave Intermediate 4 (450 mgs, 76percent yield).1H-NMR (CDCl3, 300 MHz) delta=7.62 (s, 1H), 7.51 (d, J=8.1 Hz, 2H), 7.41 (d, J=8.1 Hz, 2H), 7.18-7.24 (m, 1H), 6.840 (d, J=9.6 Hz, 1H), 5.39 (s, 2H), 4.54-4.60 (m, 1H), 2.12 (s, 3H), 1.31 (s, 3H), 1.27 (s, 3H).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,10602-04-7, (4-Ethynylphenyl)methanol, and friends who are interested can also refer to it.
Reference:
Patent; ALLERGAN, INC.; US2012/129906; (2012); A1;,
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