Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 60666-70-8, name is (2-Bromo-5-chlorophenyl)methanol. A new synthetic method of this compound is introduced below., HPLC of Formula: C7H6BrClO
Compound 17-3 (0421) To a solution of compound 17-2 (8.0 g, 36.1 mmol) in THF (60 mL) was added NaH (60percent, 1.88 g, 46.9 mmol) at 0° C. After addition, the reaction mixture was stirred at room temperature for 30 min. Iodomethane (10.25 g, 72.2 mmol) was added and stirred for another 30 min. The reaction was then quenched with sat. ammonium chloride (50 mL) and extracted with ethyl acetate (50 mL×3). The combined organic layers were washed with brine (60 mL), dried over Na2SO4, filtered, concentrated to afford 17-3 as a white solid (7.23 g, yield 85percent).
If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 60666-70-8, (2-Bromo-5-chlorophenyl)methanol.
Reference:
Patent; Nivalis Therapeutics, Inc.; Wasley, Jan; Rosenthal, Gary J.; Sun, Xicheng; Strong, Sarah; Qiu, Jian; US9138427; (2015); B2;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts