With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.504-63-2, name is 1,3-Propanediol, molecular formula is C3H8O2, molecular weight is 76.0944, as common compound, the synthetic route is as follows.Application In Synthesis of 1,3-Propanediol
General procedure: To a solution of substrate (1 mmol) and acetic anhydride (1.5 mmol) was added supported iron catalyst (Fe/SBA-15) (0.005 mmol, 0.085 g) and the mixture was stirred at 40 C. After completion of the reaction (TLC), the reaction mixture was filtered and the catalyst rinsed with ethyl acetate and heated at 70 C prior to its reuse in the next reaction. The organic layer was washed with saturated NaHCO3 and water, and dried over anhydrous sodium sulfate. The product was obtained after removal of the solvent.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,504-63-2, 1,3-Propanediol, and friends who are interested can also refer to it.
Reference:
Article; Rajabi, Fatemeh; Luque, Rafael; Catalysis Communications; vol. 45; (2014); p. 129 – 132;,
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