With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.60211-57-6, name is 3,5-Dichlorobenzyl alcohol, molecular formula is C7H6Cl2O, molecular weight is 177.0279, as common compound, the synthetic route is as follows.Application In Synthesis of 3,5-Dichlorobenzyl alcohol
Step 1.Preparation of {7-[4-(3,5-Dichloro-benzyloxy)-benzylsulfanyl]-indan-4-yloxy}-acetic Acid Methyl Ester (Compound 77A) The product from Example 75C (0.42 g, 1 mmoles), (3,5-dichlorophenyl)-methanol (0.24 g, 1.3 mmoles), triphenyl phosphine (0.38 g, 1.5 mmoles), and 0.23 ML of diethyl azodicarboxylate (0.25 g, 1.5 mmoles) were dissolved in 9 ML of tetrahydrofuran.The reaction mixture was stirred at room temperature under nitrogen for 18 hrs.The reaction mixture was evaporated to give a residue, which was flash chromatographed (silica gel, 20% ethyl acetate in hexane) to afford the title compound in good purity. MS m/z 265
At the same time, in my other blogs, there are other synthetic methods of this type of compound,60211-57-6, 3,5-Dichlorobenzyl alcohol, and friends who are interested can also refer to it.
Reference:
Patent; Auerbach, Bruce J.; Bratton, Larry D.; Filzen, Gary F.; Geyer, Andrew G.; Trivedi, Bharat K.; Unangst, Paul C.; US2003/225158; (2003); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts