Synthetic Route of 4654-39-1 ,Some common heterocyclic compound, 4654-39-1, molecular formula is C8H9BrO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
Dissolve 31.6 g of iodine, 33.9 g of triphenylphosphine and 22.4 mg of imidazole in anhydrous dichloromethane (100 mL), After cooling in an ice bath for 30 minutes, 20.0 g of p-bromobenzyl alcohol was dissolved in anhydrous dichloromethane (50 mL) and quickly added dropwise to the reaction bottle.Remove the ice bath and react at room temperature for about 6 hours.Distill off the methylene chloride, add a water-methanol mixture solution (400mL, water: methanol volume ratio of 1:3), transfer to a separatory funnel, add n-heptane extraction (200mL×3), shake vigorously until the whole system is free The color is transparent and the organic layers are combined.It was dried over anhydrous sodium sulfate, and the organic solvent was distilled off to obtain a colorless transparent solid, that is, compound 11. The product was stored in the dark and the yield was 93.2%.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 4654-39-1, 2-(4-Bromophenyl)ethanol, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Chinese Academy Of Medical Sciences Pharmaceutical Institute; Shi Zeyu; Chen Si; Xiao Qiong; Zhang Xiang; Tian Yulin; Yin Dali; (11 pag.)CN111087358; (2020); A;,
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