Adding a certain compound to certain chemical reactions, such as: 41175-50-2, 1,2,3,5,6,7-Hexahydropyrido[3,2,1-ij]quinolin-8-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, name: 1,2,3,5,6,7-Hexahydropyrido[3,2,1-ij]quinolin-8-ol, blongs to alcohols-buliding-blocks compound. name: 1,2,3,5,6,7-Hexahydropyrido[3,2,1-ij]quinolin-8-ol
Method A – From US 3,932,415 7,7′-Methylenebis(2,3,6,7-tetrahydrobenzo[i,j]quinolizine-8,8′-diol)Hydrochloric acid (0.8 cm3, 32%) was added drop wise to a solution of 8-hydroxyjulolidine (3.00 g, 15.9 mmol) in methanol (16 cm3) at 5C. Formalin (0.593 cm3, 40% in water) was then added to the reaction and the resulting mixture was allowed to stand overnight at 5C. The mixture was then poured into water (50 cm3) before being neutralised with a saturated solution of sodium bicarbonate. The mixture was extracted with chloroform (3 x 40 cm3), the combined extracts were dried over sodium sulphate, filtered and the solvent removed under reduced pressure. Column chromatography (3:7 ethyl acetate/hexane) gave the target material as a colourless solid (2.11 g, 68%).deltaH (250 MHz, CDCI3): 6.68 (2H, s, CH), 3.64 (2H, s, CH2), 3.00 (8H, t, J1 = 6 Hz, CH2), 2.67 (4H, J1 = 6 Hz, CH2), 2.60 (4H1 1, J2 = 7 Hz1 CH2), 1.97 – 1.90 (8H, m, CH2); deltac (100 MHz, CDCI3): 149.3, 142.7, 127.6, 114.6, 114.5, 108.5, 50.2, 49.4, 30.9, 27.0, 22.5, 21.7, 21.2; vmax (KBr)/cm 1: 3431 , 2927, 2853, 2842, 1618, 1494, 1450, 1350, 1332, 1310, 1281 , 1270, 1153, 1132; m/z (ESI): 389.3 (100%, [M-H]+).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,41175-50-2, 1,2,3,5,6,7-Hexahydropyrido[3,2,1-ij]quinolin-8-ol, and friends who are interested can also refer to it.
Reference:
Patent; WISTA LABORATORIES LTD.; CLUNAS, Scott; STRORY, John, Mervyn, David; RICKARD, Janet, Elizabeth; HORSLEY, David; HARRINGTON, Charles, Robert; WISCHIK, Claude, Michel; WO2010/67078; (2010); A2;,
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