Adding a certain compound to certain chemical reactions, such as: 1875-88-3, 2-(4-Chlorophenyl)ethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 1875-88-3, blongs to alcohols-buliding-blocks compound. name: 2-(4-Chlorophenyl)ethanol
Example 8A: To a solution of 2-(4-chlorophenyl)ethanol (250 mg, 1.60 mmol, 215 mu, 1 eq) and Et3N (243 mg, 2.40 mmol, 333 mu, 1.50 eq) in DCM (5 mL) at 0 C was added methanesulfonyl chloride (340 mg, 2.97 mmol, 230 mu, 1.86 eq). The solution was stirred at 0 C for 2 hours. Water (30 mL) was added to the solution. The organic layer was separated, dried over anhydrous sodium sulfate, and concentrated to afford the target compound (350 mg, 93% yield). The product can be used directly for the next step without further purification. MR (400 MHz, METHANOLS) delta 7.35 – 7.21 (m, 4H), 4.43 (t, J= 6.6 Hz, 2H), 3.04 (t, J= 6.6 Hz, 2H), 2.98 (s, 3H).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1875-88-3, its application will become more common.
Reference:
Patent; CHRYSALIS, INC.; GWALTNEY, Stephen; (167 pag.)WO2017/143011; (2017); A1;,
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