10/9/2021 News Extracurricular laboratory: Synthetic route of 52244-70-9

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 52244-70-9, 4-(4-Methoxyphenyl)-1-butanol.

Related Products of 52244-70-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 52244-70-9, name is 4-(4-Methoxyphenyl)-1-butanol. This compound has unique chemical properties. The synthetic route is as follows.

EXAMPLE 7 [0194] (a) trans-4-[4-(4-Phenyl-cyclohexylamino)butyl]phenol [0195] (b) trans-4-{4-[Methyl(4-phenylcyclohexyl)amino]butyl}phenol [CHEMMOL-00019] [0196] Step 1: To an ice-cold, stirred solution of alcohol 16 (1.5 g, 8.3 mmol) in TBF (40 mL), under an N2 atmosphere, was added Et3N (1.7 mL, 12 mmol) followed by methanesulfonyl chloride (0.77 mL, 10 mmol). After 1 hour, the reaction mixture was partitioned between EtOAc and 1N HCl. The organic layer was washed with H2O, saturated NaHCO3, saturated NaCl, dried (Na2SO4), and filtered. Concentration under reduced pressure gave mesylate 17 (2.2 g, 100percent), which was used without further purification: 1H NMR (300 MHz, CD3OD) ? 7.10 (d, J=8.5 Hz, 2H), 6.82 (d, J=8.5 Hz, 2H), 4.25-4.20 (m, 2H), 3.75 (s, 31), 3.03 (s, 31), 2.62-2.56 (m, 2H), 1.73-1.40 (m, 4H).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 52244-70-9, 4-(4-Methoxyphenyl)-1-butanol.

Reference:
Patent; Deorazio, Russell Joseph; Nikam, Sham Shridhar; Scott, Ian Leslie; Sherer, Brian Alan; Wise, Lawrence David; US2003/225164; (2003); A1;,
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