Reference of 403-41-8, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 403-41-8, name is 1-(4-Fluorophenyl)ethyl Alcohol. A new synthetic method of this compound is introduced below.
0039] H Equipped with a magnetic stirrer in round bottom flask methyl benzyl alcohol (12. 22g, 100. Ommol, namely formula The R1 is 4-methyl, R2 is hydrogen, X is carbon, eta is 1, m is 0), ferric chloride (0. 81g, 5mmol), L- isoleucineAcid (1.31g, 10mmol), TEMP0 (1.56g, 10mmol), toluene 300. OmL was added , then the reaction with oxygen in the air bottleReplacement, stirred and reflux for 6h. After completion of reaction, the reaction mixture was cooled to room temperature, filtered, the filtrate evaporated to give the crude product,The resultant crude product was purified by column chromatography, with n-hexane: Elution: (10 1 volume ratio) mixed liquid of ethyl acetate containing the desired collectionLabeled compound of the eluent, evaporation of the solvent and dried to give the product p-tolualdehyde 10. 93g, 91% yield. 1- (4-fluorophenyl) ethanol (1 · 40g, 10. Ommol, i.e., of formula (I), R1 is 4-fluoro,R2 is methyl, X is carbon, [eta] is l, m is 0) is used, experimental methods and procedures were the same as in Example 1, except that: trifluoromethanesulfonate Iron(0 · 50g, 1. Ommol), L- isoleucine (0 · 26g, 2 · Ommol), TEMPO (0 · 16g, 1 · Ommol), xylene 30. OmL,After stirring at reflux with oxygen reaction bottle of air displacement 48h. To give the final product 1.23g, 88% yield.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,403-41-8, 1-(4-Fluorophenyl)ethyl Alcohol, and friends who are interested can also refer to it.
Reference:
Patent; Zhejiang University; Zhang, Guofu; Li, Shasha; Ding, Chengrong; Zhang, Guihua; Xie, Xiaoqiang; Lei, Jie; (12 pag.)CN105294413; (2016); A;,
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