Adding a certain compound to certain chemical reactions, such as: 5456-63-3, trans-2-Aminocyclohexanol hydrochloride, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, HPLC of Formula: C6H14ClNO, blongs to alcohols-buliding-blocks compound. HPLC of Formula: C6H14ClNO
A mixture of 5-chloro-6-ethyl-3-{3-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]anilino}pyrazine-2-carboxamide (11, 150 mg,0.307 mmol), rac-(1R,2R)-2-aminocyclohexan-1-ol monohydrochloride(140 mg, 0.921 mmol), DIPEA (164 muL, 0.921 mmol) and NMP (3 mL) was irradiated with microwaves at 190 C for 60 min. After the mixture was cooled, water was added, and the resulting precipitate was filtered. The obtained solid was purified by silica gel column chromatography(CHCl3/MeOH=84:16) to give 12b (61 mg, 35%) as a brown solid. 1HNMR (DMSO-d6): delta 1.05-1.32 (4H, m), 1.20 (3H, t, J=7.5 Hz),1.45-1.59 (2H, m), 1.59-1.74 (2H, m), 1.74-1.86 (2H, m), 1.86-2.04(2H, m), 2.14 (3H, s), 2.18-2.67 (13H, m), 3.20-3.41 (2H, m),3.48-3.61 (1H, m), 3.73-3.87 (1H, m), 3.82 (3H, s), 4.64 (1H, d,J=5.0 Hz), 6.56 (1H, d, J=7.5 Hz), 6.79 (1H, d, J=8.5 Hz),7.10-7.23 (3H, m), 7.48 (1H, d, J=2.5 Hz), 11.03 (1H, s); MS (ESI) m/z [M+H]+ 567; HRMS (ESI) m/z Calcd for C30H47N8O3 [M+H]+:567.3766, Found: 567.3768.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,5456-63-3, trans-2-Aminocyclohexanol hydrochloride, and friends who are interested can also refer to it.
Reference:
Article; Iikubo, Kazuhiko; Kurosawa, Kazuo; Matsuya, Takahiro; Kondoh, Yutaka; Kamikawa, Akio; Moritomo, Ayako; Iwai, Yoshinori; Tomiyama, Hiroshi; Shimada, Itsuro; Bioorganic and Medicinal Chemistry; vol. 27; 8; (2019); p. 1683 – 1692;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts