Synthetic Route of 60666-70-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 60666-70-8, name is (2-Bromo-5-chlorophenyl)methanol, molecular formula is C7H6BrClO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Step 1. ((2-Bromo-5-chlorobenzyl)oxy)(tert-butyl)dimethylsilane. Triethylamine (0.30 mL, 2.15 mmol), DMAP (97 mg, 0.79 mmol) and tert-butyldimethylsilyl chloride (TBSCl; 698 mg, 4.63 mmol) were added to a solution of (2-bromo-5-chlorophenyl)methanol (500 mg, 2.26 mmol) in CH2Cl2 (11.3 mL) at room temperature. After stirring overnight, the reaction mixture was partitioned between saturated aqueous sodium bicarbonate (50 mL) and CH2Cl2 (200 mL). The phases were separated and the aqueous phase was extracted with CH2Cl2 (2*100 mL). The combined organic phase was washed with brine, dried (MgSO4), filtered and concentrated in vacuo.
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 60666-70-8, (2-Bromo-5-chlorophenyl)methanol.
Reference:
Patent; Allergan, Inc.; Ngo, Vinh X.; Old, David W.; Burk, Robert M.; (55 pag.)US9540357; (2017); B1;,
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