With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.928-92-7, name is 4-Hexen-1-ol, molecular formula is C6H12O, molecular weight is 100.16, as common compound, the synthetic route is as follows.Formula: C6H12O
trans-4-hexene-1-ol(16, 40.0 g, 0.4 mol) and Et3N (48.5 g, 0.48 mol) weredissolved in toluene 400 mL. MsCl (50.3 g, 0.44 mol) was then dropped into this solution,which was cooled with ice, keeping the reaction temperature at 25C or less. After agitatingfor 1 hr, brine 200 mL was added. The organic layer was washed twice using 5 wt%NaHCO3 solution 500 mL and water 500 mL. After drying with MgSO4, the toluene wasconcentrated. As a result, 4-hexene-1-mesylate (17, 69.5 g, 0.39 mol, yield: 97.5%) wasobtained as a colorless, oily substance.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,928-92-7, 4-Hexen-1-ol, and friends who are interested can also refer to it.
Reference:
Article; Gotoh, Yasuyuki; Ushioda, Makoto; Molecular Crystals and Liquid Crystals; vol. 593; 1; (2014); p. 61 – 77;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts