Synthetic Route of 30379-58-9, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.30379-58-9, name is Benzyl 2-hydroxyacetate, molecular formula is C9H10O3, molecular weight is 166.17, as common compound, the synthetic route is as follows.
To a solution of anhydrous CH2Cl2 (3 mL), 4 A mol. sieves (0.1 g), protected glycolicacid 6 (150 g, 0.91 mmol) and compound 5 (500 g, 0.91 mmol) was added, at 20 C under argon atmosphere, TMSOTf (15 muL, 0,075 mmol). Afterwards the reaction mixture was stirred at this temperature for 3 h until TLC showed full conversion (PE:EtOAc 7:3, Rf 0.3). Than the mixture wasquenched by the addition of Et3N, filtered and the residue washed with CH2Cl2 (100 mL). The organic layer was concentrated. Pd-C catalyst was added to a solution of the oily mixture obtained from the previous reaction in 75 mL of (1:1) THF-MeOH. Afterwards, under stirring, the reaction mixture was placed under an H2 gas atmosphere (atmospheric pressure) and the deprotection of the benzyl ester was continued overnight. When full conversion had taken place (TLC examination), the H2 flow was replaced by Argon and the reaction mixture was filtered and washed (MeOH, 200 mL) through a pad of Celite. Upon concentration of the filtrate, a white solid material was obtained, and added CH2Cl2 was evaporated to remove traces of MeOH to afford 7 as a white solid (274 g, 0.6 mmol, 65% yield).
The chemical industry reduces the impact on the environment during synthesis 30379-58-9, I believe this compound will play a more active role in future production and life.
Reference:
Article; Ghidini, Alice; Steunenberg, Peter; Murtola, Merita; Stromberg, Roger; Molecules; vol. 19; 3; (2014); p. 3135 – 3148;,
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