07/9/2021 News Extracurricular laboratory: Synthetic route of 162358-05-6

With the rapid development of chemical substances, we look forward to future research findings about 162358-05-6.

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 162358-05-6, name is 2-(4-Octylphenyl)ethanol. This compound has unique chemical properties. The synthetic route is as follows. name: 2-(4-Octylphenyl)ethanol

Example 17 Preparation of 4-octylphenethyl methanesulfonate 2-(4-Octylphenyl)ethanol (53 g) and dichloromethane (500 mL) are charged into a 1 liter three-neck round bottom flask equipped with guard tube and addition funnel. Triethylamine (83.5 g) is added, the mixture is stirred for 30 minutes, then it is cooled to 0 C. Methanesulphonyl chloride (35.2 mL) is added drop-wise at 0 C. and the mass is stirred for 3 hours at room temperature. The mass is diluted with water (700 mL) and the organic layer is separated and the aqueous layer is extracted with dichloromethane (2*250 mL). The combined organic layers is washed with saturated sodium bicarbonate (500 mL) and brine solution (500 mL). The organic layer is separated, dried with sodium sulphate, and concentrated under vacuum to obtain the title compound. Yield: 70 g.

With the rapid development of chemical substances, we look forward to future research findings about 162358-05-6.

Reference:
Patent; DR. REDDY’S LABORATORIES LTD.; Katkam, Srinivas; Sagyam, Rajeswar Reddy; Morthala, Raghavendar Rao; Ireni, Babu; Vinigari, Krishna; Ramdoss, Suresh Kumar; Rangineni, Srinivasulu; Tummala, Arjunkumar; Iqbal, Javed; Oruganti, Srinivas; Kandagatla, Bhaskar; US2014/235895; (2014); A1;,
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