Related Products of 68327-04-8, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.68327-04-8, name is (1S,2S)-2-Aminocyclopentanol hydrochloride, molecular formula is C5H12ClNO, molecular weight is 137.6079, as common compound, the synthetic route is as follows.
A solution of 128 mg intermediate 6-(4-chlorophenyl)-2-(1 -methyl-i H-pyrazol-4-yl)-3-oxo-2,3- dihydropyridazine-4-carboxylic acid (46%), 50 mg (1 S,2S)-2-aminocyclopentanol hydrochloride (1:1), 135 mg HATU, 0.13 mL ethyldiisopropylamine and 1 mg 4-dimethylaminopyridine in 1 mL of DMF was stirred at room temperature for 14 hours. Then the reaction mixture wasfiltered and subjected to RP-HPLC (instrument: Labomatic HD-3000 HPLC gradient pump, Labomatic Labocol Vario-2000 fraction collector; column: Chromatorex 0-18 125 mm x 30 mm, eluent A: 0.ivol% formic acid in water, eluent B: acetonitrile; gradient: A 70% I B 30% – A 30% I B 70%; flow: 150 mLlmin; UV-detection: 254 nm) to yield 3 mg 6-(4-chlorophenyl)-N- [(1 S ,2S)-2-hyd roxycyclopentyl]-2-(i -methyl-i H-pyrazol-4-yl)-3-oxo-2 ,3-d ihyd ropyridazine-4-carboxamide.1H NMR (400 MHz, DMSO-d6) 6 [ppm] = 1.38- 1.58 (m, 2 H), 1.60- 1.79 (m, 2 H), 1.80- 1.89(m, 1 H), 2.03 -2.18 (m, 1 H), 3.93 (s, 3 H), 3.94 – 3.99 (m, 1 H), 3.99 -4.07 (m, 1 H), 4.97 (d,1 H), 7.55 – 7.65 (m, 2 H), 8.07 – 8.14 (m, 3 H), 8.52 – 8.60 (m, 2 H), 9.44 (d, 1 H).
Statistics shows that 68327-04-8 is playing an increasingly important role. we look forward to future research findings about (1S,2S)-2-Aminocyclopentanol hydrochloride.
Reference:
Patent; BAYER AKTIENGESELLSCHAFT; BAYER PHARMA AKTIENGESELLSCHAFT; DEUTSCHES KREBSFORSCHUNGSZENTRUM; GUTCHER, Ilona; ROeHN, Ulrike; SCHMEES, Norbert; ZORN, Ludwig; ROeSE, Lars; BADER, Benjamin; KOBER, Christina; CARRETERO, Rafael; STOeCKIGT, Detlef; IRLBACHER, Horst; PLATTEN, Michael; (397 pag.)WO2018/146010; (2018); A1;,
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