Reference of 3637-61-4, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 3637-61-4, name is Cyclopentanemethanol. This compound has unique chemical properties. The synthetic route is as follows.
Cyclopentanemethanol (263 muL, 2.5 mmol, 5 eq) was added to a suspension of NaH (98 mg, 2.5 mmol, 5 eq) in THF (5 mL) at 0C. The reaction was stirred at 0C for 30 min and 6-(6-bromopyridin-2-yl)-3-[(2-chloro-4-fluorophenyl)sulfanyl]-6-(thiophen- 3-yl)piperidine-2,4-dione (250 mg, 0.49 mmol, 1 eq) was added. The reaction was then stirred overnight under reflux and quenched by the addition of water (10 mL) and HC1 1 M (5 mL). The aqueous phase was extracted with ethyl acetate (3 x 15 mL) and the combined organic phases were dried with Na2S04, filtered and concentrated under reduced pressure. The crude product was purified by flash chromatography on silica gel (eluent: heptane/ ethyl acetate: 75/25) to give 3-[(2-chloro-4- fluorophenyl)sulfanyl]-6-[6-(cyclopentylmethoxy)pyridin-2-yl]-6-(thiophen-3- yl)piperidine-2,4-dione (192 mg, 0.36 mmol) in 74 % yield. 1H NMR (MeOD-d4, 400 MHz): delta = 7.71 (dd, J= 8.0, 7.6 Hz, 1H), 7.44 (dd, J= 8.8, 7.2 Hz, 1H), 7.27 (dd,J=2.8, 1.2 Hz, 1H), 7.15-7.11 (m, 2H), 7.09 (dd,J=4.8, 2.8 Hz, 1 H), 6.75 (d, J= 8.4 Hz, 1 H), 6.54 (td, J= 8.4, 2.8 Hz, 1H), 5.99 (dd, J= 8.8, 6.0 Hz, 1H), 4.27-4.18 (m, 2H), 3.87 (d,J= 16.4 Hz, 1H), 3.45 (d,J = 16.4 Hz, 1H), 2.36-2.28 (m, 1H), 1.83-1.74(m, 2H), 1.66-1.53 (m, 4H), 1.39-1.29 (m, 2H). I C NMR (MeOD-d4, 100 MHz): delta = 166.9, 161.6, 158.6 (d,J= 245 Hz), 157.2, 143.5, 138.2, 130.7 (d, J = 4 Hz), 124.8 (d,J= 8.5 Hz), 124.7, 124.5, 120.1, 114.7 (d, J=25 Hz), 112.3 (d,J=21 Hz), 111.8, 108.0, 100.0,68.3,59.3,39.1,37.3,27.5, 23.4.
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 3637-61-4, Cyclopentanemethanol.
Reference:
Patent; ARCTIC PHARMA AS; GOLDING, Louise; KLAVENESS, Jo; SIENG, Bora; LUNDVALL, Steffi; BØEN, Claudia Alejandra; HNIDA, Kathrin; (128 pag.)WO2018/211277; (2018); A1;,
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