Electric Literature of 22436-06-2 , The common heterocyclic compound, 22436-06-2, name is (S)-2-Methyl-3-phenylpropan-1-ol, molecular formula is C10H14O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
General procedure: Methanesulfonyl chloride (6.29 mmol) was added dropwise to asolution of the alcohol (5.72 mmol) and diisopropylethylamine (8.58 mmol) in DCM (20.5 mL) at 0 C and warmed to room temperature. After 90 min, the mixture was partitioned with distilled water (2*20 mL), 1M HCl (2*10 mL), and brine (20 mL). The organic layer was dried (MgSO4), filtered, and concentrated under vacuum to give the desired compound, which was taken forward without purification
The synthetic route of 22436-06-2 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Shouksmith, Andrew E.; Evans, Laura E.; Tweddle, Deborah A.; Miller, Duncan C.; Willmore, Elaine; Newell, David R.; Golding, Bernard T.; Griffin, Roger J.; Australian Journal of Chemistry; vol. 68; 4; (2015); p. 660 – 679;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts