Reference of 431-38-9, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 431-38-9, name is 3-Amino-1,1,1-trifluoropropan-2-ol. A new synthetic method of this compound is introduced below.
Into a microwave vial under an inert atmosphere of N2, were placed intermediate from Step B (220 mg, 0.40 mmol), in N-methyl-2-pyrrolidinone (3 mL) and THF (3 mL), and 3-amino-1,1,1-trifluoropropan-2-ol (207 mg, 1.60 mmol). The mixture wasirradiated with microwave radiation at 180 C for 3 h, then cooled to RT, quenched with water (100 mL), and extracted with EtOAc (3 x 100 mL). The combined organic layer was washed with water (2 x 100 mL), dried over anhydr. Na2SO4, filtered and concentrated in vacuo to dryness. The residue was purified by column chromatography with MeOH/DCM (0- 5%) to afford the racemic title compound, which was resolved by chiral-prep-HPLC ColumnPhenomenex Lux 5u Cellulose-4, to afford isomers A (faster eluting) and B (slower eluting) of the title compound.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,431-38-9, 3-Amino-1,1,1-trifluoropropan-2-ol, and friends who are interested can also refer to it.
Reference:
Patent; MERCK SHARP & DOHME CORP.; WHITEHEAD, Alan; ORNOSKI, Olga; RAGHAVAN, Subharekha; BERGER, Raphaelle; GARFUNKLE, Joie; YANG, Zhiqiang; JI, Gang; JIANG, Falong; FU, Jianmin; (132 pag.)WO2017/197555; (2017); A1;,
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