As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 61826-40-2, name is (2-Phenylcyclopropyl)methanol, molecular formula is C10H12O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. name: (2-Phenylcyclopropyl)methanol
EXAMPLE 16 To a stirred and cooled (temp.?0 C.) solution of 63 parts of 2-phenylcyclopropanemethanol in 378 parts of 1,1′-oxybisethane were added dropwise 63 parts of phosphor tribromide. The mixture was allowed to reach room temperature while stirring and the whole was further stirred for 30 minutes at room temperature. The reaction mixture was poured onto 90 parts of ice water and the layers were separated. The organic layer was washed successively twice with water and once with a sodium hydrogen carbonate solution, dried, filtered and evaporated. The residue was distilled, yielding 67 parts (74.5%) of (1-bromo-3-butenyl)benzene; bp. 85-94 C. at 0.4 mm. pressure (129).
With the rapid development of chemical substances, we look forward to future research findings about 61826-40-2.
Reference:
Patent; Janssen Pharmaceutica N.V.; US4861785; (1989); A;; ; Patent; Janssen Pharmaceutica N.V.; US5010198; (1991); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts