Application of 5343-92-0, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.5343-92-0, name is 1,2-Pentanediol, molecular formula is C5H12O2, molecular weight is 104.1476, as common compound, the synthetic route is as follows.
Prepare 55g sodium hydrogen (2.3mol) under nitrogen protectionAnd a suspension of 200 ml of tetrahydrofuran,Slowly add 1,2-pentanediol 125g (1.2mol) under micro refluxa mixture with 200 ml of tetrahydrofuran,There is a constant flow of gas to produce a discharge system.No gas is produced after stirring for 10 hours.A sodium salt suspension is obtained for use.After replacing the air in the 2000 mL autoclave with nitrogen,After adding 300 ml of tetrahydrofuran under nitrogen protection,Maintain internal temperature -10 ~ 0 C into the sulfuryl fluoride 151.6g (1.48 mol),The sodium salt suspension was continuously added to the kettle, and the reaction was kept for 2 hours.After the reaction, the nitrogen blowing system removes excess sulfuryl fluoride gas.The reaction solution was filtered and then decomposed to dryness under reduced pressure.The crude product was added with 300 ml of dichloromethane, 15-crown-5 0.1 g,18-crown-6 0.1g, refluxing for 1h,After filtration, the product was dried (162.7 g) (two-step yield 85.1%)
The chemical industry reduces the impact on the environment during synthesis 5343-92-0, I believe this compound will play a more active role in future production and life.
Reference:
Patent; Shanghai Kangpeng Technology Co., Ltd.; Quzhou Kangpeng Chemical Co., Ltd.; He Li; Li Xiaoliang; Tian Zhong; Yang Jianhua; (12 pag.)CN108409708; (2018); A;,
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