Synthetic Route of 15852-73-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 15852-73-0, name is (3-Bromophenyl)methanol, molecular formula is C7H7BrO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
General procedure: In a typical reaction procedure, bromobenzene (0.4 mmol),4-methylbenzeneboronic acid (0.1 mmol), Pd1Ni4/ZrO2 alloy catalyst and Na2CO3 (1 equiv.) were added into a reactor (10 mL) equipped with a magnetic stirrer and EtOH (2 mL) was added as the solvent. The reaction mixture was stirred at 80 °C under an N2 atmosphere for 4 h. After reaction, the catalyst was separated by simple filtration and the solution was analysed by GC and GC?MS. For isolation of the products, the solvent was removed under reduced pressure. The residue was purified by flash chromatography on a silica column, using ethylacetate and n-hexane as the eluent. The NMR data for the products agreed with the literature
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 15852-73-0, (3-Bromophenyl)methanol.
Reference:
Article; Zhang, Li-Jie; Yao, Xian; Sun, Ying-xin; Zhang, Jia-wei; Cai, Chun; Journal of Chemical Research; vol. 42; 8; (2018); p. 419 – 423;,
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