Synthetic Route of 3973-18-0, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 3973-18-0 as follows.
2-(Prop-2-ynyloxy)ethyl-lflr,l^,27/,2^-perfluorodecane-l-sulfonate (20); In a 25 mL round bottomed flask, distilled triethylamine (0.24 mL, 1.7 mmol) followed by lH,lH,2H,2H-perfluorodecane sulfonyl chloride (273 mg, 0.5 mmol) were added to a solution of 2-(prop-2-ynyloxy)ethanol (140 mg, 1.4 mmol) in DCM (3.0 mL) at 0C under a nitrogen atmosphere. The mixture was allowed to stir for 3 hours before being quenched with NaHCO3, extracted with DCM, and the organic phases dried over MgSO4. The solvent was removed under reduced pressure to give a crude solid product. Purification by column chromatography on silica gel (15% Et2O in hexane) afforded the target product as a white solid (71 mg, 0.12 mmol, 23% yield).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,3973-18-0, its application will become more common.
Reference:
Patent; ISIS INNOVATION LIMITED; GOUVERNEUR, Veronique; BEJOT, Romain; WO2010/7363; (2010); A2;,
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