With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.23147-58-2, name is Glycerol aldehyde dimer, molecular formula is C4H8O4, molecular weight is 120.1039, as common compound, the synthetic route is as follows.name: Glycerol aldehyde dimer
The compound (209.3 mg) obtained in Example 89-2 was dissolved in anhydrous methanol (8.4 ml). Then, the solution was added with [1,4]dioxan-2,5-diol (54.0 mg) and sodium cyanoborohydride (56.6 mg) and adjusted to pH 5 with acetic acid, followed by stirring at room temperature for 19.5 hours. After the reaction, the solvent was distilled off. Subsequently, the residue was added with a 1 mol/l sodium hydroxide aqueous solution (1.0 ml), followed by extraction with chloroform. The extract was dried with magnesium sulfate and the solvent was then distilled off. The residue was purified through silica gel column chromatography (chloroform/methanol) and then treated with hydrochloric acid, thereby obtaining hydrochloride (175.8 mg) of the subject compound as a white solid. MS(FAB,Pos.):m/z=510[M+H]+1H-NMR(500MHz,DMSO-d6+D2O):delta=0.92(6H,t,J=7.1Hz),1.64-1.68(6H,m),1.78-1.82(2H,m),3.00-3.08(10H,m),3.71(3H,s),3.74(4H,s),4.09(2H,s),4.17(2H,s),4.30 (2H,q,J=13.9Hz),7.41(2H,d,J=7.8Hz),7.48(4H,d,J=5.6Hz),7.61(2 H,s).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,23147-58-2, Glycerol aldehyde dimer, and friends who are interested can also refer to it.
Reference:
Patent; Kureha Chemical Industry Co., Ltd.; EP1550657; (2005); A1;,
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