Electric Literature of 6301-54-8 , The common heterocyclic compound, 6301-54-8, name is 2-(Naphthalen-1-yl)propan-2-ol, molecular formula is C13H14O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
A mixture of 13 (31.66 g, 0.17 mol) and 2% sulfuric acid(600 mL) was stirred at reflux until the reaction completed as indicated by TLC analysis (typically within 2 h). On cooling to room temperature, the reaction mixture was extracted with CH2Cl2 (500 mL 3). The combined extracts were washed with 5% brine (500 mL), dried (Na2SO4) and evaporated on arotary evaporator to give a residue, which was purified by column chromatography to afford the pure product 2-(naphth-1-yl)propene (14) as a colorless oil (24.02 g, 84%). 1H NMR (CDCl3, 400 MHz) : 8.03-8.06 (m, 1H), 7.82-7.85(m, 1H), 7.74 (d, 1H, J = 8.0 Hz), 7.40-7.48 (m, 3H), 7.30(dd, 1H, J = 1.2 Hz and 3.4 Hz), 5.39-5.40 (m, 1H), 5.05 (d,1H, J = 1.2 Hz), 2.20 (s, 3H). The 1H NMR data were ingood agreement with those reported [18].
The synthetic route of 6301-54-8 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Zhang, Xiansheng; Wu, Jingwei; Liu, Wei; Liu, Yuqiang; Xie, Yafei; Shang, Qian; Zhou, Zhixing; Xu, Weiren; Tang, Lida; Wang, Jianwu; Zhao, Guilong; Medicinal Chemistry; vol. 13; 3; (2017); p. 260 – 281;,
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