Electric Literature of 558-42-9 , The common heterocyclic compound, 558-42-9, name is 1-Chloro-2-methyl-2-propanol, molecular formula is C4H9ClO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
Compound 10-a (77 mg, 0.177 mmol) was dissolved in a mixed liquid of methanol and water (1/1, v/v, 5 mE), and to the solution were added sodium carbonate (28 mg, 0.266 mmol) and 1 -chloro-2-methyl-propan-2-ol (28 mg, 0.266 mmol). The reaction solution was stirred at 80° C. overnight. The reaction mixture was diluted with saturated brine, and the aqueous layer was extracted with ethyl acetate. The separated organic phase was dried over anhydrous sodium sulfate, and concentrated under reduced pressure. The residue was purified by Prep -HPEC to obtain compound 13 (35 mg, 39percent). EC-MS (ESI): mlz=507.3 (M+H). ?H NMR (400 MHz, CDC13): oe 8.32 (1H, s), 7.74 (1H, s), 7.68 (1H, s), 7.49 (1H, d, J=8.0 Hz), 7.26-7.29 (2H, m), 6.98 (1H, s), 3.91 (4H, d, J=4.8 Hz), 3.77-3.90 (6H, m), 2.58-2.64 (8H, m), 2.27 (2H, s), 1.09 (6H, s).
The synthetic route of 558-42-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; SHANGHAI YINGLI PHARMACEUTICAL CO., LTD; XU, Zusheng; (174 pag.)US2016/214994; (2016); A1;,
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