Adding a certain compound to certain chemical reactions, such as: 558-42-9, 1-Chloro-2-methyl-2-propanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 558-42-9, blongs to alcohols-buliding-blocks compound. Recommanded Product: 558-42-9
A solution of 5 -fluoro-3 -nitropyridin-2( 1 H)-one (0.7058 g, 4.46 mmol), 1 -chloro2-methylpropan-2-ol (1.454 g, 13.39 mmol), potassium carbonate (1.234 g, 8.93 mmol) and sodium iodide (2.008 g, 13.39 mmol) in DMF (22.32 ml) in a pressure tube was heated to 125 °C and stirred overnight. LCMS showed ?1 :1 starting material:desiredproduct. The reaction was cooled to room temperature. EtOAc (150 mL) was added, and the solution was filtered through Celite®. The filtrate was washed with brine (40 mL), and the organic layer was dried over Na2SO4, filtered and concentrated in vacuo to give a residue which was purified by flash chromatography using an ISCO 80g column (solid loading) eluting with 20-100percent EtOAc/hexane. Appropriate fractions were collected andconcentrated in vacuo to give 5-fluoro-1-(2-hydroxy-2-methylpropyl)-3-nitropyridin-2(1H)-one (0.127 g, 0.497 mmol, 11.12 percentyield).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,558-42-9, its application will become more common.
Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; LIU, Chunjian; LIN, James; MOSLIN, Ryan M.; WEINSTEIN, David S.; TOKARSKI, John S.; WO2015/89143; (2015); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts