Reference of 29055-08-1, Adding some certain compound to certain chemical reactions, such as: 29055-08-1, name is (2-(Methylamino)phenyl)methanol,molecular formula is C8H11NO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 29055-08-1.
To a solution (50 [ML)] of [2- (methylamino) phenyl] methanol (1.37 g: synthesized according to the method described in WO 01/32652) in tetrahydrofuran were added pyridine (1.05 [ML),] acetic anhydride (1.23 [ML)] and 4-dimethylaminopyridine (0.18 g), and the mixture was stirred at room temperature for 8 hrs. Water (100 mL) was added to the reaction mixture, and the mixture was extracted with ethyl acetate (100 mL). The organic layer was washed successively with a 5percent aqueous copper (II) sulfate solution (50 mL), a saturated aqueous sodium hydrogen carbonate solution (50 mL) and saturated brine (50 mL), and dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure and the obtained residue was purified by flash silica gel column chromatography (eluted with ethyl acetate: hexane=1 : 5, then 1: 3) to give the title compound (0.38 g) as a white solid. [H-NMR] [(CDCL3)] [: 2.] 08 (3H, s), 2.87 (3H, s), 4.40 [(LH,] br), 5.08 (2H, s), 6.64-6. 74 (2H, m), 7.17-7. 32 (2H, m).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 29055-08-1, (2-(Methylamino)phenyl)methanol, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; TAKEDA CHEMICAL INDUSTRIES, LTD.; WO2003/105845; (2003); A1;,
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