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Reference of 3637-61-4 ,Some common heterocyclic compound, 3637-61-4, molecular formula is C6H12O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

lodomethylcyclopentane; Methanesulfonyl chloride (13.8 ml_, 178 mmol) was added drop wise and at 0 C to a solution of cyclopentanemethanol (16.2 g, 162 mmol) in anhydrous pyridine (35 ml_). The mixture was stirred at 0C for 5 h, poured into water (200 ml_), and extracted with methylene chloride (3 x 50 ml_). The combined organic layers were washed with 1 M HCI (3 x 20 ml_) and brine (2 x 20 ml_), dried with anhydrous magnesium sulphate, and evaporated in vacuo. The residue was dissolved in anhydrous acetone (20 ml_), and a solution of sodium iodide (24 g, 162 mmol) in acetone (50 ml_) was added. The mixture was refluxed for EPO 5 h. The formed precipitate was filtered off, and the filtrate was evaporated in vacuo. The residue was distilled and the fraction boiling at 71 -75 C (1 10 Torr) was collected to give iodomethylcyclopentane. Yield: 13.8 g (41 %). 1H-NMR (CDCI3, delta ppm): 3.21 (d, J=6.9 Hz, 2 H); 2.18 (hept, J=7.5 Hz, 1 H); 1.95-1.45 (m, 6 H); 1.35- 1.11 (m, 2 H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,3637-61-4, its application will become more common.

Reference:
Patent; NOVO NORDISK A/S; WO2006/58923; (2006); A1;,
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