New downstream synthetic route of

Adding a certain compound to certain chemical reactions, such as: 63478-76-2, 6-Heptyn-1-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, COA of Formula: C7H12O, blongs to alcohols-buliding-blocks compound. COA of Formula: C7H12O

Part A: Synthesis of tert-butyl(hep iIane To a stirred solution of hept-6-yn-l-ol (5.3 g, 47.25 mmol) in dry THF (450 ml) was added imidazole (7.08 g, 103.95 mmol) followed by tert-butyldimethylsilylchloride (7.83 g, 51.97 mmol) under nitrogen. The mixture was stirred for 16 h at room temperature before water (200 ml) and hexane (250 ml) were added. The layers were separated and the aqueous phase was extracted with hexane. The combined organic phases were dried over MgSO4, filtered and concentrated to give the protected alcohol. The crude product was purified by column chromatography (SiO2, 0 – 1.5% ethyl acetate in petroleum spirit) to give the pure tert-butyl(hept-6-ynyloxy)dimethylsilane as a colourless oil (8.23 g, 77%). The product was used immediately in the next reaction step.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,63478-76-2, 6-Heptyn-1-ol, and friends who are interested can also refer to it.

Reference:
Patent; COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION; WO2009/111830; (2009); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts