Month: August 2021

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 2568-33-4, name is 3-Methylbutane-1,3-diol. A new synthetic method of this compound is introduced below., Application In Synthesis of 3-Methylbutane-1,3-diol

Example 19; Synthesis of Chain Transfer Agent; CTA-14.; 17 g (40 mmol) of 3-methyl-1,3-butanediol and 20.0 mL of tetrahydrofuran (THF) were weighed and placed in a 500 mL round bottom flask. The temperature of the system was adjusted to 25 C. and the mixture was stirred. After adding 18.98 g (240 mmol) of pyridine, 36.6 g (240 mmol) of S-acetyl mercaptoacetic acid chloride were added thereto dropwise over 30 minutes. After the addition, the mixture was aged at 25 C. for 5 hours. Subsequently, 20 mL of toluene and 20 mL of pure water were added thereto followed by stirring and the oil phase was concentrated. 35.0 g of the concentrate was weighed and placed in a 500 mL round bottom flask and 100 mL of methanol was added thereto. 200 mL of a saturated sodium bicarbonate solution was then added thereto dropwise over 30 minutes with cooling on an ice bath. Four hours after completion of the addition, 50 mL of pure water and 100 mL of ethyl acetate were added thereto and the mixture was stirred. The oil phase of the reaction solution was concentrated. The concentrate was recrystallized using hexane to give 5.04 g of CTA-1 shown below (yield 50%).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 2568-33-4, 3-Methylbutane-1,3-diol.

Reference:
Patent; Mitsubishi Rayon Co., Ltd.; US2009/198065; (2009); A1;,
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Related Products of 7397-62-8 ,Some common heterocyclic compound, 7397-62-8, molecular formula is C6H12O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

59.23 g of 99.5% magnesium ethoxide was added to the obtained n-butyl glycolate, and the alcohol formed by the reaction was simultaneously removed at 60 C. After the reaction, 154.42 g of 99% o-dichlorobenzene was added thereto, and the condensation reaction was carried out at 90 C. After the reaction, the unreacted o-dichlorobenzene was decompressed under reduced pressure, and the condensation liquid was cooled to 35 C for filtration. The filter cake was dried under reduced pressure, and the dried fraction was collected and combined with the filtrate to obtain n-butyl o-chlorophenoxyacetate (243.96 g). The content is 98.4%, and the yield is 98.9%.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,7397-62-8, its application will become more common.

Reference:
Patent; Shandong Runbo Biological Technology Co., Ltd.; Sun Guoqing; Chi Zhilong; Hou Yongsheng; Zhang Liguo; Hu Yishan; (8 pag.)CN108947816; (2018); A;,
Alcohol – Wikipedia,
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Adding a certain compound to certain chemical reactions, such as: 14320-38-8, Cyclopent-3-enol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Safety of Cyclopent-3-enol, blongs to alcohols-buliding-blocks compound. Safety of Cyclopent-3-enol

Step A(3-cyclopenten-1-yloxy)(1 , 1-dimethylethyl)dimethylsilane[00177] A solution of 3-cyclopenten-l-ol (2.0 g, 23.78 mmol) in DMF (79 ml) was cooled to 0 C and treated by the addition of imidazole (3.56 g, 52,3 mmol) followed by the addition of TBDMSC1 (4.30 g, 28.5 mmol). The reaction mixture was stirred at room temperature overnight, diluted with EtOAc and washed with 5% LiCl (3 ), brine, dried (Na2S04), Filtered, andconcentrated. The crude residue was purified by silica gel chromatography (0-10%EtOAc/Hexanes) to give the title product (5.19 g, 100%).

The synthetic route of 14320-38-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; GLAXOSMITHKLINE LLC; BANKA, Anna; CATALANO, John, G.; CHONG, Pek, Yoke; FANG, Jing; GARRIDO, Dulce, Maria; MAYNARD, Andy; MILLER, John; PATTERSON, Dan; PEAT, Andrew, James; POWERS, Jeremiah; PRICE, Daniel, J.; ROBERTS, Chris; TAI, Vincent; YOUNGMAN, Michael; WO2011/50284; (2011); A1;,
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Synthetic Route of 3068-00-6 , The common heterocyclic compound, 3068-00-6, name is 1,2,4-Butanetriol, molecular formula is C4H10O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

A 100 mL RBF was charged with dilinolenyl ketone (Compound 55) (4.2 g, 8.2 mmol), 1,2,4-butanetriol (3.4 g, 32 mmol), PPTS (200 mg, 0.8 mmol) and a stir bar. The flask was flushed with nitrogen and anhydrous toluene (60 mL) added. The reaction vessel was fitted with a Dean Stark tube and condenser and brought to reflux and the reaction was left overnight. After cooling to room temperature, the reaction mixture diluted with toluene (50 mL), and washed with 5% aq. Na2CO3 (2 x 50 mL), water (50 mL), dried (MgSO4) and purified by chromatography to yield 3.0 g (4.9 mmol, 59%) of the ketal.

The synthetic route of 3068-00-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; PROTIVA BIOTHERAPEUTICS, INC.; HEYES, James; PALMER, Lorne; MASLOWSKI, Magdalena; MACLACHLAN, Ian; WO2011/106; (2011); A1;,
Alcohol – Wikipedia,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 55414-72-7, name is (2-Amino-5-methoxyphenyl)methanol, the common compound, a new synthetic route is introduced below. Formula: C8H11NO2

Compound 4 (216 mg, 1.41 mmol) and MnO2 (900 mg,10.4 mmol) were dissolved in dry THF (20 mL). The reaction mixture was stirred under nitrogen atmosphere at room temperature for 4 h. After that time another portion of MnO2 (900 mg,10.35 mmol) was added, followed by a third portion of MnO2 (900 mg, 10.35 mmol) after the same time interval. The reaction mixture was stirred under N2 atmosphere at room temperature for a total of 24 h. The mixture was filtered through a layer of celiteand washed with small amount of THF. The filtrate was evaporated under reduced pressure to produce the title compound as a brown oil (225 mg, 99%); 1H NMR (400 MHz, CDCl3) d 9.85 (d, J = 0.3 Hz,CHO), 7.01 (dd, J = 8.8, 2.9 Hz, ArH4), 6.96 (d, J = 2.9 Hz, ArH6),6.63 (d, J = 8.8 Hz, ArH3), 5.83 (s, 2H, NH2), 3.79 (s, 3H, OCH3),13C{1H} NMR (101 MHz, CDCl3) d 193.7, 150.9, 144.9, 124.8,118.6, 117.9, 116.9, 56.0. This compound is unstable at room temperature and must be kept in a vial filled with nitrogen gas at 20C; for this reason it was not fully characterised.

The synthetic route of 55414-72-7 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Lizarme, Yuvixza; Wangsahardja, Jonatan; Marcolin, Gabriella M.; Morris, Jonathan C.; Jones, Nicole M.; Hunter, Luke; Bioorganic and Medicinal Chemistry; vol. 24; 7; (2016); p. 1480 – 1487;,
Alcohol – Wikipedia,
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