Month: August 2021

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 15258-73-8, name is (2,6-Dichlorophenyl)methanol, molecular formula is C7H6Cl2O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Recommanded Product: (2,6-Dichlorophenyl)methanol

To a solution of 2,6-dichlorobenzyl alcohol (22 mg, 0.13 mmol, 1.0 eq) in tetrahydrofuran (1.5mL) was added sodium hydride (25 mg, 0.99 mmol, 7.8 eq) and the resulting reaction mixturewas stirred at 23 C. After 10 minutes a solution of 4-{5-[3-chloro-4- (dimethylcarbamoyl)phenylj -3-cyanopyridin-2-yl } piperazine- 1 -carbonyl chloride (55 mg, 0.13 mmol, 1.0 eq) in dichloromethane (1.5 mL) was added and the reaction mixture was stirred at 23C for 16 hours. The excess sodium hydride was quenched with the dropwise addition of water(0.15 mL), the mixture was concentrated and the residue was dissolved in DMSO and purified byreverse phase liquid chromatography (Gemini-NX C18, 5 jim, 30 x 100 mm column; 0-100%CH3CN/H20 gradient w/ 0.10% TFA present) to yield 2,6-dichlorobenzyl 4-{5-[3-chloro-4-(dimethylcarbamoyl)phenylj -3-cyanopyridin-2-yl } piperazine- 1 -carboxylate. ?H NMR (400MHz, CD3OD): oe 8.69 (d, J = 2.5 Hz, 1 H); 8.29 (d, J = 2.5 Hz, 1 H); 7.79 (d, J = 1.7 Hz, 1 H);7.67 (dd, J = 8.0, 1.7 Hz, 1 H); 7.48-7.33 (m, 4 H); 5.44 (s, 2 H); 3.85-3.58 (m, 8 H); 3.13 (s, 3H); 2.92 (s, 3 H). LRMS m/z (M+H) 572.2 found, 572.1 required.

With the rapid development of chemical substances, we look forward to future research findings about 15258-73-8.

Reference:
Patent; MERCK SHARP & DOHME CORP.; RUDD, Michael, T.; BRNARDIC, Edward, J.; KIM, Yuntae; MEISSNER, Robert, S.; RADA, Vanessa; STACHEL, Shawn, J.; ZERBINATTI, Celina, V.; (125 pag.)WO2017/83216; (2017); A1;,
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Synthetic Route of 929-06-6, Adding some certain compound to certain chemical reactions, such as: 929-06-6, name is 2-(2-Aminoethoxy)ethanol,molecular formula is C4H11NO2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 929-06-6.

To a round-bottomed flask containing dichloromethane (15 mL), 2-(2-aminoethoxy)ethanol1 (1.580 g, 15.03 mmol) was added. The solution was kept in ice bath (0 C). A dichloromethanesolution (9 mL) containing di-tert-butyl dicarbonate (3.726 g, 17.07 mmol) was added dropwise (25 min)to the round-bottomed flask. The progress of this amine protection reaction could be convenientlymonitored using TLC. The reaction was carried out at room temperature for 6.5 h.After the reaction, the mixture was washed first with 10 wt% citric acid (10 mL), then10 wt% NaHCO3 (10 mL 2), and finally with water (10 mL). The organic layer collected wasdried over anhydrous Na2SO4, filtered and concentrated under reduced pressure. The residuewas purifed by column chromatography (ethyl acetate /hexane = 1:3, v/v) to aord tert-butyl(2-(2-hydroxyethoxy)ethyl)carbamate (2.646 g, 86% yield) as colorless liquid.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 929-06-6, 2-(2-Aminoethoxy)ethanol, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Li, Hsin-Yi; Chu, Yen-Ho; Molecules; vol. 25; 1; (2020);,
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As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 4654-39-1, name is 2-(4-Bromophenyl)ethanol, molecular formula is C8H9BrO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Formula: C8H9BrO

A mixture of 2-(4-bromophenyl)ethan-1-ol (60 g, 300 mmol), BISPIN (84 g, 330 mmol), KOAc (90 g, 900 mmol) and PdC (dppf) (6.6 g, 9 mmol) in 1 ,4-dioxane (600 ml) was stirred under N2at 85C for 16 h. The RM was cooled to RT, filtered, the filtrate was concentrated and the residue purified by chromatography on silica gel eluting with EtOAc in petroleum ether (from 0 to 30%) to afford of the title compound as an oil (100 g).Method J: Rt = 1.87 min, [M+NH4]+= 266.

With the rapid development of chemical substances, we look forward to future research findings about 4654-39-1.

Reference:
Patent; NOVARTIS AG; ARISTA, Luca; HEBACH, Christina; HOLLINGWORTH, Gregory John; HOLZER, Philipp; IMBACH-WEESE, Patricia; LORBER, Julien; MACHAUER, Rainer; SCHMIEDEBERG, Niko; VULPETTI, Anna; ZOLLER, Thomas; (178 pag.)WO2019/186343; (2019); A1;,
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Synthetic Route of 25392-41-0, Adding some certain compound to certain chemical reactions, such as: 25392-41-0, name is 4-(Chloromethyl)-7-hydroxy-2H-chromen-2-one,molecular formula is C10H7ClO3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 25392-41-0.

Take the above crude product (2g, 9.50mmol) in a 200ml single-necked flask.Add 1N NaOH solution (100ml),The solution immediately turns thick yellow,The above solution was placed in an oil bath and heated at reflux for 2 h.After the reaction,Cool to room temperatureThe pH was adjusted to 2-3 with concentrated sulfuric acid, and the resulting solution was extracted with ethyl acetate (30 ml x 4).Combine the organic phase,Wash with saturated brine (20ml x 2)Drying with anhydrous sodium sulfate,filter,The filtrate was evaporated under reduced pressure to give a tan brown columnar crystal of 1.3 g, and the crude yield was 71.2%.The above crude product (1 g, 5.20 mmol) was suspended in 10 ml of methanol.0.5ml concentrated sulfuric acid was added dropwiseAfter dripping, the temperature is increased to reflux for about 4 hours.After the reaction,Remove methanol under reduced pressureThe residual liquid is poured into 30 ml of water,Extract with ethyl acetate (20ml×3)Combine the organic phase,Wash with saturated sodium bicarbonate solution (15ml×2)Saturated brine (15ml x 2) washes,Drying with anhydrous sodium sulfate,filter,The filtrate was evaporated under reduced pressure to give a tan oil.Column chromatography (petroleum ether/ethyl acetate, 80:20, v/v) gave 0.75 g of a pale yellow solid in 70% yield.

According to the analysis of related databases, 25392-41-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; China Pharmaceutical University; Huang Wenlong; Qian Hai; Li Zheng; Wang Xuekun; Jiao Lei; Qiu Qianqian; (29 pag.)CN105017242; (2018); B;,
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Adding a certain compound to certain chemical reactions, such as: 1074-61-9, (4-Vinylphenyl)methanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, SDS of cas: 1074-61-9, blongs to alcohols-buliding-blocks compound. SDS of cas: 1074-61-9

Step A 1-Bromomethyl-4-vinyl-benzene Bromine (16.4 g, 103 mmol) was slowly added to a solution of triphenylphosphine (28.87 g, 110.1 mmol) in CH2Cl2 (260 mL) at 0 C. After 10 minutes, 4-vinylbenzyl alcohol (12.5 g, 93.3 mmol) was added and the reaction mixture was stirred at 0 C. for 2 h. The reaction mixture was washed with water (1*) followed by brine (1*). The organic solution was dried over MgSO4, filtered, and concentrated in vacuo. The product was triturated with petroleum ether (3*), and the ethereal solution was concentrated in vacuo. The residue was purified by flash chromatography (hexanes) to afford 4-vinyl-benzyl bromide (6.23 g). 1H NMR (400 MHz, CDCl3) delta7.32-7.45 (m, 4H), 6.72 (dd, 1H), 5.77 (d, 1H), 5.28 (d, 1H), 4.50 (s, 2H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1074-61-9, (4-Vinylphenyl)methanol, and friends who are interested can also refer to it.

Reference:
Patent; Pfizer Inc.; US6344485; (2002); B1;,
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Adding a certain compound to certain chemical reactions, such as: 37585-16-3, (2-Amino-4-chlorophenyl)methanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: (2-Amino-4-chlorophenyl)methanol, blongs to alcohols-buliding-blocks compound. Recommanded Product: (2-Amino-4-chlorophenyl)methanol

A solution of (2-amino-4-chlorophenyl)methanol (5.00 g, 31.85 mmol) and pyridine (3.1 mL) in anhydrous chloroform (150 mL) was treated dropwise with a solution of 4- chlorobenzenesulfonyl chloride (7.26g ,34.58 mmol) in chloroform (30 mL) over 20 minutes at room temperature. The reaction mixture was stirred for 5 hours and evaporated to dryness. The resulting residue was taken up in ethyl acetate (200 mL) and aqueous ammonium chloride (100 mL). After stirring for 30 minutes the organic phase was separated and further washed with dilute ammonium chloride (2 x 50 mL), dried EPO over sodium sulfate, filtered and evaporated to give an oil. This was triturated in hot hexane (10OmL) and then stirred at ambient temperature for 2 hours. The solid was collected and washed with hexane to give the title compound (10.0 g). HPLC Rt = 3.04 minutes. 1H NMR (CDCI3) delta 7.75 (d, 2H), 7.53 (s, 1H), 7.45 (d, 2H), 7.09 (dd, 1 H), 7.01 (d, 1 H), 4.40 (s, 2H).

The synthetic route of 37585-16-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; GLAXO GROUP LIMTED; WO2007/14054; (2007); A2;,
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Reference of 55414-72-7, Adding some certain compound to certain chemical reactions, such as: 55414-72-7, name is (2-Amino-5-methoxyphenyl)methanol,molecular formula is C8H11NO2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 55414-72-7.

The product of preparation 3 (300mg, 2.0mmol) in tetrahydrofuran (3mL) was added dropwise to a suspension of sodium hydride (60% dispersion in mineral oil, 54mg, 2.3mmol) in tetrahydrofuran (2mL). The mixture was stirred for 45 minutes and the temperature was maintained at -10C. The product of preparation 5 (357mg, 1.3mmol) in tetrahydrofuran (3mL) was added dropwise and the mixture was stirred for a further hour. The temperature was then allowed to increase to 25C and the reaction was quenched with sodium hydrogen carbonate solution (5mL), and diluted with ethyl acetate (20mL) and water (10mL). The organic phase was separated, washed with brine (10mL), dried over magnesium sulfate and concentrated in vacuo to give an oily residue. Purification of the oil by column chromatography on silica gel, eluting with dichloromethane: methanol, 100: 0 to 97: 3, afforded the title compound in 59% yield, 300mg. MS APCI+ m/z 390,392 [MH]+

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 55414-72-7, (2-Amino-5-methoxyphenyl)methanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; PFIZER LIMITED; PFIZER INC.; WO2005/121152; (2005); A1;,
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As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 156-87-6, name is 3-Aminopropan-1-ol, molecular formula is C3H9NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Computed Properties of C3H9NO

A solution of 3-aminopropan-1-ol (3 g, 39.9 mmol) and benzaldehyde (4.05 mL, 39.9 mmol) in methanol (200 mL) was stirred at room temperature overnight. The solution was cooled to 0 C., and sodium borohydride (1.813 g, 47.9 mmol) was added slowly in several portions. The resulting mixture was stirred at room temperature for three hours, and then it was partitioned between water and dichloromethane (3*). The organic extracts were combined and dried over Na2SO4, the drying agent was removed by filtration, and the solution was concentrated in vacuo to give the title compound as an oil (6.5 g, 98%)

With the rapid development of chemical substances, we look forward to future research findings about 156-87-6.

Reference:
Patent; ABBVIE INC.; Bhatia, Pramila A.; Randolph, John T.; Schrimpf, Michael R.; Zhang, Quinwei I.; US2014/171423; (2014); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 5391-88-8, 1-(4-Bromophenyl)ethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 5391-88-8, blongs to alcohols-buliding-blocks compound. Recommanded Product: 5391-88-8

General procedure: Bi(OTf)3 (1.0 mol%) was added to a solution of the appropriate secbenzylalcohol (1.0 equiv) and TMSN3 (1.2 equiv) in CH2Cl2 (4.0mL/mmol) at r.t. When the reaction was complete (TLC), the solventwas removed and the crude material was purified by column chromatography.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,5391-88-8, its application will become more common.

Reference:
Article; Tummatorn, Jumreang; Thongsornkleeb, Charnsak; Ruchirawat, Somsak; Thongaram, Phanida; Kaewmee, Benyapa; Synthesis; vol. 47; 3; (2015); p. 323 – 329;,
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Adding a certain compound to certain chemical reactions, such as: 27489-62-9, trans-4-Aminocyclohexanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 27489-62-9, blongs to alcohols-buliding-blocks compound. Product Details of 27489-62-9

To a mixture of trans-4-aminocyclohexanol (2.07 g, 13.6 mmol) and NaHCCbeta (3.50 g, 41.7 mmol) in H2O (20 mL) at room temperature, a solution of benzyl chloroformate (1.92 mL, 13.6 mmol) in dioxane (15 mL) was added. The mixture was stirred at room temperature for 20 h. The white precipitate was collected as benzyl (lR,4R)-4- hydroxycyclohexylcarbamate (3.37 g).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,27489-62-9, its application will become more common.

Reference:
Patent; PORTOLA PHARMACEUTICALS, INC.; WO2009/131687; (2009); A2;,
Alcohol – Wikipedia,
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