Analyzing the synthesis route of

Application of 4728-12-5 ,Some common heterocyclic compound, 4728-12-5, molecular formula is C7H14O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

(5) 4-(2.2-Dimethyl-1 ,3-dioxan-5-ylmethoxy)-2.3,5-trimethylpyridine 1 -oxideA mixture of 4-chloro-2,3,5-trimethylpyridine 1-oxide (840 g), (2,2-dimethyl-1 ,3-dioxan-5-yl)methanol (688 g), and toluene (2.52 L) was heated and refluxed while removing water. While continuing the azeotropic dehydration, potassium hydroxide (0.58 kg) was added thereto over 3 hours 45 minutes, and then the azeotropic dehydration was continued for a further 2.5 hours. The reaction system was then cooled to below 30 0C, ethyl acetate (2.5 L) and 17percent brine solution (3.5 L) were added thereto, and the reaction system was allowed to stand overnight. The ethyl acetate layer was separated off, and the aqueous layer was subjected to extraction with ethyl acetate (1.0 L x 3). The ethyl acetate layers were combined, and filtered through Celite, and then vacuum concentration was carried out, whereby 1.20 kg of the target substance was obtained.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,4728-12-5, its application will become more common.

Reference:
Patent; Eisai R & D Management Co., Ltd.; WO2008/47849; (2008); A1;,
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