As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 171011-37-3, name is (4-Bromo-1,2-phenylene)dimethanol, molecular formula is C8H9BrO2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. name: (4-Bromo-1,2-phenylene)dimethanol
To a solution of (COCl)2 (2.6 equiv.) in anhydrous DCM (1.4 mL per mmol of diol) was added dropwise a solution of anhydrous DMSO (5.2 equiv.) in anhydrous DCM (2.2 mL per mmol of diol) at -78 C and under a nitrogen atmosphere. After 10 min stirring at -78 C, a solution of diol (1.0 equiv.) in anhydrous DCM (2.2 mL per mmol of diol) was added at this temperature. The reaction mixture was stirred at -78 C for 1h under a nitrogen atmosphere before Et3N (1.4 mL per mmol of diol) was added dropwise. The reaction mixture was warmed to rt and stirred for 2-18 h under a nitrogen atmosphere. The reaction was then quenched by addition of H2O. The organics were extracted with DCM, combined, washed with water, washed with brine, dried over MgSO4 and concentrated in vacuo to afford the desired o-phthaldialdehyde.
With the rapid development of chemical substances, we look forward to future research findings about 171011-37-3.
Reference:
Article; D’Hollander, Agathe C.A.; Westwood, Nicholas J.; Tetrahedron; vol. 74; 2; (2018); p. 224 – 239;,
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