Synthetic Route of 534-03-2, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 534-03-2, name is 2-Aminopropane-1,3-diol. A new synthetic method of this compound is introduced below.
Preparation of the compound of formula (III) starting from the isolated compound (II), in the presence of calcium hydroxide. Calcium hydroxide (12.8 g, 0.173 mol) was slowly added, under stirring and keeping the temperature below 25C, to a solution of compound (II) (120 g, 0.169 mol) in 305 g of DMA.Further on, to the reaction mixture a solution of 2-amino-l,3-propandiol in DMA (133 g, 28% w/w, 0.406 mol) was added dropwise in a period of time of about 45 minutes. The mixture was kept at about 300C for 10 hours, up to the completion of the reaction. The crude reaction material containing the derivative of formula (III) may be purified and hydro lyzed according to the procedure of the Example 3 below. HPLC profile of the mixture after treatment of the sample with NaOH: Iopamidol (IV): 97.9%; F-impurity: 0.2%.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,534-03-2, 2-Aminopropane-1,3-diol, and friends who are interested can also refer to it.
Reference:
Patent; BRACCO IMAGING SpA; CERAGIOLI, Silvia; CIARCIELLO, Giovanni; INCANDELA, Salvatore; MINOTTI, Pietro; WO2010/57765; (2010); A1;,
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