Synthetic Route of 57772-50-6, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 57772-50-6 as follows.
Example 4: An aromatic amino alcohol of formula II (R1 = R2 = R4 = R5 = hydrogen, R3 = 3-methyl, 13.48 g, 98 mmol) was dissolved in a THF/diethoxymethane mixture (1 :1, v:v) (73 g) and charged with water (93 g). The agitated brown mixture was cooled to about 12 C. A parallel dosage of gaseous phosgene (13.7 g, 139 mmol) and 25% aqueous NaOH (62.9 g, 393 mmol) was performed within 1 h wherein the pH was kept between 8 and 9 and the temperature in the reaction vessel was kept at 7 to 17 0C. At the end of the phosgene addition the reaction mixture was additionally agitated for 1 h at 12 C. After workup procedure according to example 1 and drying 100% of compound of formula I (R1 = R2 = R3 = R4 = R5 = hydrogen, 16.19 g) was obtained.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,57772-50-6, its application will become more common.
Reference:
Patent; LONZA LTD; GRIFFITHS, Gareth-John; LORENZI, Miriam; WARM, Aleksander; WO2010/115640; (2010); A1;,
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