Synthetic Route of 109-83-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 109-83-1, name is 2-(Methylamino)ethanol, molecular formula is C3H9NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
4-fluoro benzaldehyde in dry DMSO (35ml) (5.0g, 40.29mmol) and 2- To a stirred solution of (methylamino) ethanol (3.63g, 48.34mmol), under an argon atmosphere K2CO3 ( 6.68g, 48.34mmol) was added. The reaction mixture was then heated for 3 days at 120 . Then added to the reaction mixture which was cooled in water (400ml), and extracted with EtOAc (7 × 100ml). The combined organic layers were washed with brine (2 × 100ml), dried (Na2SO4), the solvent was removed under reduced pressure to give an oil of high viscosity orange. Which solidified slowly at room temperature. This solid was dissolved in DCM (40ml) and then a yellow solid precipitated by adding the solution to hexanes (200 ml), was collected yellow solid by filtration under vacuum. Recrystallization from toluene, the title compound (4.47g, 62%) was obtained as small yellow thin plate material.
According to the analysis of related databases, 109-83-1, the application of this compound in the production field has become more and more popular.
Reference:
Patent; WISTA LABORATORIES LIMITED; KEMP, STEVEN JOHN; STOREY, LYNDA JANE; STOREY, JOHN MERVYN DAVID; RICKARD, JANET; HARRINGTON, CHARLES ROBERT; WISCHIK, CLAUDE MICHEL; CLUNAS, SCOTT; HEINRICH, TOBIAS KERST; (269 pag.)JP5667058; (2015); B2;,
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