Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1450754-41-2, name is 2-(3-But-3-ynyl-3H-diazirin-3-yl)-ethanol. A new synthetic method of this compound is introduced below., Computed Properties of C7H10N2O
To a solution of ethan1-ol (200 mg,145 mrnoi, 1 equiv) in tetrahydrofuran (10 mL) at 24 C, was added carbonyidiimidazole(950 mg, 580 mmol, 4.00 equiv). The mixture was allowed to stir for 12 hours at 24 eQ Theproduct mixture was concentrated in vacuo to a solid residue. The residue was directly loadedto a hexaneequilibrated silica gel column and the desired material was eluted using a 50–100% ethyl acetate-hexane solvent, two steps). The irnidazole 5 was isolated as colorless oilafter concentration of the residual soR nt (320 mRf= 0.15 (40 ethyl acetate—he?ane; LV). f- NMR (500 MHz, ()Cl.). 8.13 (s, I]1 7.42-7..-1 I ,m, IH, H-. 7.03—7.u2 ,ni. I H 4.26—4 23 a. 2Ff, 7 1 :-iz, F).L99–i.96(m.3RHR:). I H–I S8(t,2H.i==Hz.H). I 6(– I 6{t,2H.i==7.I Hz.H). ?( >R (125 MHz. CDCI ). d I?4X.3 (C). I 7. I (CH. 130 7 Ci). 117. 1 ( H), 82 3(( , 6 (( H). o2 ) {OCH). 32 QH , 32.1) (( RI, 26.0 (CN , I . I ((?Ri) IR (AE R-FTIR) cm? 3291 (brj, 3 1 8 (w) 3 132 (rn,j, 2960 (w), 2921 (m,j, 2858 (m) 1 758 (s), 1588(s). 1525 mL 1473 (m). 1444 (m), 1404 (in), 1350 (w), 1316 (w). 1282 (? . 1240 (w), 1173(w), 1095 (m), 1058 (m) 1003 (v, 898 (m), 833 , 768 (w), 749 ( 6-l (v, 598 (w),526 (w). HRMSESI (m/z) [. L calculated for C H 1N4O2, 233. 1039. Ibund. 233.1064.
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Reference:
Patent; PRESIDENT AND FELLOWS OF HARVARD COLLEGE; WOO, Christina, M.; GAO, Jinxu; (555 pag.)WO2018/226828; (2018); A2;,
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