The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 4740-78-7, name is 1,3-Dioxan-5-ol. This compound has unique chemical properties. The synthetic route is as follows. category: alcohols-buliding-blocks
[00768] To a solution of compound 263-1 (2 g, 6.55 mmol, 1 eq) in THF (2 mL) were added compound 263-la (1.02 g, 9.83 mmol, 1.5 eq) and PPh3 (2.58 g, 9.83 mmol, 1.5 eq). The mixture was degassed with N2 for 3 times. Then DIAD (1.99 g, 9.83 mmol, 1.9 mL, 1.5 eq) was added to the mixture dropwised at 0C. The mixture was stirred at 20C for 16 hr. LCMS showed that the starting material was remained and 33% of desired product was detected. TLC (PE/EA = 3/1, UV) showed that several spots were formed. The reaction mixture was concentrated in vacuum and the residue was diluted with EA (20 mL), washed with water (5 mL) and brine (5 mL). The organic phase was dried over Na2S04, filtered and concentrated in vacuum. The crude product was purified by column chromatography (Si02). Compound 263 (1.3 g, 2.79 mmol, 42.6% yield) was obtained. LCMS (ESI): RT = 0.885 min, mass calcd. For Ci8Hi6F3N502,391.13 m/z found 392.0 [M+H] +; 1HNMR (400 MHz, CDC13) 9.02 (s, 1H), 8.20 (dd, J= 7.92, 1.38 Hz, 1H), 7.51- 7.58 (m, 3H), 7.35- 7.42 (m, 1H), 7.30 (d, J= 8.54 Hz, 2H), 7.03- 7.08 (m, 1H), 5.12 (s, 1H), 4.85- 4.94 (m, 2H), 4.65- 4.80 (m, 2H), 4.00 – 4.07 (m, 2H).
With the rapid development of chemical substances, we look forward to future research findings about 4740-78-7.
Reference:
Patent; VIVACE THERAPEUTICS, INC.; KONRADI, Andrei W.; LIN, Tracy Tzu-Ling Tang; (396 pag.)WO2018/204532; (2018); A1;,
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