Application of 37729-18-3, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 37729-18-3, name is 2-([1,1′-Biphenyl]-4-yl)ethanol. A new synthetic method of this compound is introduced below.
Compound 30:Acrylic acid (13.5 mg, 0.05 mmol) was added sequentially to a 25 mL two-necked flask,2-biphenylethyl alcohol (49.5 mg, 0.25 mmol),N, O-bis (diethylsilyl) trifluoroacetamide (213.6 mg, 0.75 mmol)Potassium peroxy monosulfonate (307.0 mg, 0.50 mmol)The gas was replaced with dry N2 for 3 times,Finally, dry tetrahydrothiopyran (0.5 mL) was added under N2.Stirred at room temperature and heated to 50 C to carry out the reaction,Until the thin layer chromatography monitoring of raw materials is completed.At the end of the reaction, 15.0 mL of NaCl solution was added at room temperature,Extracted with ether 15.0 mL three times,The combined organic phase was distilled under reduced pressure and the product was purified by column chromatography in 65% yield.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,37729-18-3, 2-([1,1′-Biphenyl]-4-yl)ethanol, and friends who are interested can also refer to it.
Reference:
Patent; Nanjing Normal University; Han Wei; Zhao Hongyuan; (19 pag.)CN107056732; (2017); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts