Electric Literature of 702-82-9 ,Some common heterocyclic compound, 702-82-9, molecular formula is C10H17NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
3.0 g of compound IV, 3.3 g of 3-amino-1-adamantanol, 2.7 g of potassium carbonate,0.1 g of potassium iodide and 30 mL of tetrahydrofuran were added to a 100 mL reaction flask and mechanically stirred.Reaction at 20 C for 12 hours,Filter, wash the filter cake with 20 mL of tetrahydrofuran, and combine the filtrate.The filtrate was concentrated to dryness at 40 C.Add 30 mL of dichloromethane, stir and dissolve, and the organic phase is passed through 10 mL of water and 10 mL respectively.Wash with brine, separate the layers, and dry the organic phase with 10 g of anhydrous sodium sulfate.filter,The organic phase was concentrated to dryness at 40 C, and then crystallised from 9mL of ethanol and 36mL of isopropyl ether.Filter, dry to constant weight at 40 C,4.4 g of compound V were obtained with a yield of 93.4%.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,702-82-9, its application will become more common.
Reference:
Patent; Zhuhai Federation Pharmaceutical Co., Ltd.; Yin Bangzhi; Mao Jiaohuang; Xu Huafeng; Qiao Mingfu; Liang Qingyong; (12 pag.)CN109776372; (2019); A;,
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