Adding a certain compound to certain chemical reactions, such as: 1072-52-2, 2-(Aziridin-1-yl)ethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Computed Properties of C4H9NO, blongs to alcohols-buliding-blocks compound. Computed Properties of C4H9NO
2-Methyl-3,4-dihydro-2H-spiro[isoquinoline-1 ,4?-piperidine] (compound obtained in example 65 step a, 268 mg, 1.23 mmol) and 2-(aziridin-1-yl)ethanol (43 jtL, 0.49mmol) were dissolved in dichioromethane in a process vial. The reaction was stirredfor few minutes and then the solvent was removed with a stream of nitrogen.Amberlyst (6 mg) was added, the vial was sealed with a septum and the reaction mixture was subjected to microwave irradiation for 3 h at 1000 C. After cooling back to r.t., the reaction was diluted with dichloromethane, and NaHCO3 was added. The phases were separated and the aqueous phase additionally extracted with DCM. The aqueous phase was then basified with NaOH solution and again extracted twice withDCM. The combined organic fractions were dried over sodium sulphate, filtered and the solvent removed to give a crude product which was purified under preparative HPLC (Column X-Bridge C18, H20+ 0.05% formic acid : ACN + 0.05% formic acid from (98:2 to 5:95), flow 20 mI/mm, rt).HPLC-MS (Method H): Ret, 1.23 mm; ESl-MS m/z, 304.2 (M+i).
The synthetic route of 1072-52-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; LABORATORIOS DEL DR. ESTEVE, S.A.; ALMANSA-ROSALES, Carmen; GARCIA-LOPEZ, Monica; CAAMANO-MOURE, Ana-Maria; (282 pag.)WO2016/78770; (2016); A1;,
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