Reference of 53463-68-6, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.53463-68-6, name is 10-Bromodecanol, molecular formula is C10H21BrO, molecular weight is 237.18, as common compound, the synthetic route is as follows.
10-Bromodecanol (50 g, 210 mmol) was oxidized using pyridiniumchlorochromate (90.5 g, 420 mmol) in CH2Cl2 (800 mL) at room temperature for 3 h. The organic layerwas filtered, and the residual was washed with petroleum. Removal of the solvent from the combinedorganic layers in vacuo gave a dark oil. The dark-colored residue was chromatographed over SiO2,and elution with hexane/EtOAc (30:1, v/v) gave crude 10-bromodecanal. Triethyl orthoformate (44.5g, 300 mmol) and p-sulphonic acid monohydrate (0.57 g, 3 mmol)were added to a stirred and ice-cooled solution of the crude 10-bromodecanal in anhydrous ethanol(300 mL). After the exothermic reaction had subsided, the mixture was left at 0 C overnight. Water wasthen added, and the mixture was made basic by adding K2CO3 solution. The mixture was extractedwith diethyl ether, and then washed with brine and dried over MgSO4. The solvent was removedunder reduced pressure and the product was chromatographed on silica (hexane/EtOAc (25:1, v/v)),which gave crude 1,l-diethoxy-10-bromodecanal.This product was converted into the title iodide by being stirred for 4 h with sodium iodide(90 g, 600 mmol) in dry acetone (500 mL) under reflux. The solvent was removed under reducedpressure, the mixture was diluted with water (200 mL), and the product was extracted withpetroleum. The extracts were washed with water, 1% Na2S2O3 solution, and brine; dried overNa2SO4; and concentrated under reduced pressure. The resulting residue was chromatographed overSiO2. Elution with hexane/EtOAc (25:1, v/v) was conducted to yield 1,l-diethoxy-10-iododecan (5) as anoil (58.8 g, 78% yield based on 10-bromodecanol); 1H-NMR (500 MHz, CDCl3) delta 1.21 (6H, t, J = 7.0 Hz),1.29 (12 H, m), 1.60 (2 H, m), 1.82 (2H, m), 3.19 (2H, t, J = 7.0 Hz), 3.49 (2H, m), 3.64 (2H, m), 4.48 (1H, t,J = 6.0 Hz); 13C-NMR (125 MHz, CDCl3) delta 102.9, 60.8, 60.8, 33.6, 33.5, 30.5, 29.4, 29.4, 29.3, 28.5, 24.7,13.4, 15.4, 7.3.
Statistics shows that 53463-68-6 is playing an increasingly important role. we look forward to future research findings about 10-Bromodecanol.
Reference:
Article; Liu, Fu; Kong, Xiangbo; Zhang, Sufang; Zhang, Zhen; Molecules; vol. 24; 9; (2019);,
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