Related Products of 1562-00-1 , The common heterocyclic compound, 1562-00-1, name is Sodium isethionate, molecular formula is C2H5NaO4S, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
To 20 g of CH3CN was added 2-hydroxyethanesulfonic acid sodium (27) 4.7 g, 2.9 g of triethylamine, 4-dimethylaminopyridine24 mg were dissolved,(24) obtained in the above (Synthesis Example 1-1-3)Was dissolved in 20 g of CH3CN dropwise at 20 or lower, The mixture was stirred at 25 for 2 hours to obtain a sulfonic acid salt (25). 20 g of CH2Cl2 and 34 g of an aqueous solution of triphenylsulfonium chloride were added, And stirred for 30 minutes. After separating the organic layer,The aqueous layer was extracted with CH2Cl2,The combined organic layers were washed three times with H2O.The solvent was distilled off under reduced pressure,8.4 g of the target compound (PAG-1) was obtained (yield of 57% in three steps).
The synthetic route of 1562-00-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Shin-Etsu Chemical Co., Ltd.; Domon, Daisuke; Masnaga, Keiichi; Sakehashi, Masayoshi; Watanabe, Satoshi; (33 pag.)KR2015/71677; (2015); A;,
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