Synthetic Route of 558-42-9, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.558-42-9, name is 1-Chloro-2-methyl-2-propanol, molecular formula is C4H9ClO, molecular weight is 108.5667, as common compound, the synthetic route is as follows.
To a solution of ethyl 9′-hydroxy-1 0′-methyl-2′-oxo-2′,7′-dihydrospiro[cyclobutane-1 ,6′-pyrido[2, 1-a]isoquinoline]-3′-carboxylate (200 mg, 0.59 mmol)in DMF (3 ml) was added K2C03 (407.1 mg, 2.95 mmol), Nal (353.7 mg, 2.36 mmol), and1-chloro-2-methylpropan-2-ol (256.2 mg, 2.36 mmol). The reaction mixture was stirred at 90 oc for 2 h. Then the reaction was extracted with DCM twice, the combined organic phaseswere washed with brine, dried over Na2S04, filtered and concentrated. The residue waspurified by chromatography (silica gel, 0-40percent CH30H in DCM) to afford the title compound(106 mg, 43.7percent yield). LCMS (ESI) m/z: 412.4 (M + 1t.
Statistics shows that 558-42-9 is playing an increasingly important role. we look forward to future research findings about 1-Chloro-2-methyl-2-propanol.
Reference:
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; CATALANO, John G.; DICKSON, Hamilton D.; KAZMIERSKI, Wieslaw Mieczyslaw; LEIVERS, Martin R.; WEATHERHEAD, John Gordon; (389 pag.)WO2018/154466; (2018); A1;,
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