Adding a certain compound to certain chemical reactions, such as: 111-46-6, 2,2′-Oxybis(ethan-1-ol), can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, SDS of cas: 111-46-6, blongs to alcohols-buliding-blocks compound. SDS of cas: 111-46-6
To a solution of 2,2′-oxodiethanol (19.7 mL, 206.7 mmol, 3.0 eq.) In anhydrous tetrahydrofuran (100 mL) was added sodium (0.1 g).Stir the mixture until the sodium mass disappears,Tert-butyl acrylate (10.0 mL, 68.9 mmol, 1.0 eq.) Was then added dropwise.The mixture was stirred overnight,Brine (200 mL) was added and extracted with ethyl acetate (3 x 100 mL). The organic layer was washed with brine (3 × 300 mL),Dried over anhydrous sodium sulfate, filtered,Concentrated and purified by silica gel column chromatography (1: 1 n-hexane / ethyl acetate),A colorless oil was obtained (8.10 g, 49.4% yield).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,111-46-6, 2,2′-Oxybis(ethan-1-ol), and friends who are interested can also refer to it.
Reference:
Patent; Hangzhou Duo Xi Biological Technology Co., Ltd.; Zhao Luoboyongxin; Huang Yuanyuan; Yang Qingliang; Gai Shun; Ye Hangbo; Xu Yifang; Guo Huihui; Cao Minjun; Li Wenjun; Cai Xiang; Zhou Xiaomai; Xie Hongsheng; Jia Junxiang; Guo Zhixiang; Lin Chen; Yang Yanlei; Ye Zhicang; Qi Tafamingrenqingqiubugongkaixingming; (338 pag.)CN110621673; (2019); A;,
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